Other names: Von Willebrand disease III, VWDIII
Affected Genes: VWF
Inheritance: Autosomal recessive
Mutations: CanFam3.1 27 g.38868884delT c.738delT
OMIA link: 001058-9615
Appropriate breeds for testing: Shetland Sheepdog


Symptoms :
Von Willebrand's disease causes a coagulation problem due to a deficiency of the von Willebrand factor protein necessary for the adhesion of blood platelets, resulting in prolonged provoked after injury. vWD disease is classified into three categories. Type I is the least severe with mild to moderate bleeding symptoms. Type II consists of vWF protein deficiency and moderate to severe defects. Type III is the most severe form of vWD.


References:
Pathak EJ. (2004) Type 3 von Willebrand’s disease in a Shetland sheepdog. Can Vet J 45:685-7. [pubmed/15368744]
Raymond SL, Jones DW, Brooks MB, Dodds WJ. Clinical and laboratory features of a severe form of von Willebrand disease in Shetland sheepdogs. J Am Vet Med Assoc. 1990 Nov 15;197(10):1342-6. [PubMed: 2266049]