Other names: Pain Insensitivity, Sensory Neuropathy, AMS, SN
Affected genes: GDNF
Transmission: Autosomal recessive
Mutation: CanFam3.1 4 g.70875561C>T
OMIA link: 001514-9615
Breeds suitable for testing : English pointer, English springer spaniel, French spaniel, German shorthaired pointer
References:
Plassais J, Lagoutte L, Correard S, Paradis M, Guaguère E, Hédan B, Pommier A, Botherel N, Cadiergues MC, Pilorge P, Silversides D, Bizot M, Samuels M, Arnan C, Johnson R, Hitte C, Salbert G, Méreau A, Quignon P, Derrien T, André C. A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies. PLoS Genet. 2016 Dec 29;12(12):e1006482. doi: 10.1371/journal.pgen.1006482. PMID: 28033318; PMCID: PMC5198995.
Acral Mutilation Syndrome (AMS, GDNF)
5 tests et + 55$ch.
After your samples are received at the laboratory, please allow 10 to 15 business days for your results to be sent.