Other Names: DINGS2, Congenital hearing and vestibular disorder, DINGS, DVD
Affected Gene: MYO7A
Transmission: Autosomal recessive
Mutation: CanFam3.1 21 g.21563111C>T c.3719G>A p.(R1240Q)
OMIA Link: 002148-9615


Breeds Recommended for Testing: Doberman Pinscher


Symptoms:
Deafness and vestibular dysfunction is a hereditary neurological disease affecting the development of the inner ears in Doberman Pinschers. The Doberman Pinscher is one of the few breeds that experience deafness associated with vestibular disease signs. Symptoms of deafness can range from mild to severe and are present by 3 weeks of age. Affected dogs also exhibit other neurological abnormalities, such as:
 
 
Head tilt
 
 
Abnormal eye movements
 
 
Circling
 
 
Uncoordinated limb usage

References:
Webb, A.A., Ruhe, A.L., Neff, M.W., Webb, A.A., Ruhe, A.L., Neff, M.W.
A missense mutation in MYO7A is associated with bilateral deafness and vestibular dysfunction in the Doberman pinscher breed.
Can J Vet Res 83:142-148, 2019. PubMed: 31097876
Strain, G.M.
Canine deafness.
Vet Clin North Am Small Anim Pract 42:1209-24, 2012. PubMed: 23122177
DOI: 10.1016/j.cvsm.2012.08.010
Wilkes, M.K., Palmer, A.C.
Congenital deafness and vestibular deficit in the Dobermann.
Journal of Small Animal Practice 33:218-224, 1992.