This panel includes multiple genetic tests related to coat color that are applicable to all dog breeds.
Included Tests:
E Locus – MC1R (Melanocortin 1 Receptor)
(Includes melanistic mask, grizzle, and red/yellow)
The MC1R gene controls the production of eumelanin (black pigment) and phaeomelanin (red/yellow pigment). Six known variants of this gene contribute to various coat patterns and colors, including melanistic masks, grizzle/domino, black, and different shades of red/yellow.

A Locus – Agouti (ASIP)
The ASIP gene interacts with MC1R to regulate red (phaeomelanin) and black (eumelanin) pigments in dogs, affecting the amount, type, and distribution of these pigments.

B Locus – Brown (TYRP1)
(Chocolate/Liver)
The TYRP1 gene dilutes eumelanin (black pigment) to brown but does not affect phaeomelanin (red/yellow pigment).

D Locus – Dilution (MLPH)
(Blue/Lilac)
Several MLPH gene variants are known to produce diluted coat colors in dogs. These variants cause the black or brown pigmentation to appear lighter (diluted), resulting in softer shades.

K Locus – Dominant Black (CBD103)
The dominant black gene (CBD103) affects pigment switching between eumelanin (black) and phaeomelanin (red/yellow) by interacting with the Agouti and MC1R genes.

S Locus – White Spotting (MITF)
White spotting patterns seen in many dog breeds do not have a uniform genetic basis, making them complex. In cases of piebald/parti/random white spotting, the extent of white expression varies, and markings are often asymmetrical.