Other name: Ivermectin sensitivity
Affected genes: ABCB1
Inheritance:  Autosomal Incomplete Dominant
Mutation: Deleted 4 bp CanFam3.1 14 g.13726596_13726599del c.228_231del p.(D77Afs*16)
OMIA link: 001402-9615

Affected breed:
Australian Shepherd, Berger Picard, Border Collie, Collie, German Shepherd, Long-Haired Whippet, McNab Shepherd, Miniature American Shepherd, Miniature Australian Shepherd, Old English Sheepdog, Rough Collie, Ryukyu Inu, Shetland Sheepdog, Shiloh Shepherd, Silken Windhound, Smooth Collie, Waller, White Swiss Shepherd

Références:
Mealey, K.L., Meurs, K.M. Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping. J Am Vet Med Assoc 233:921-4, 2008. Pubmed reference: 18795852. DOI: 10.2460/javma.233.6.921.
Mealey, KL., Munyard, KA., Bentjen, SA. Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia. Vet Parasitol 131:193-6, 2005. Pubmed reference: 15975717. DOI: 10.1016/j.vetpar.2005.05.004.
Mealey, KL., Bentjen, SA., Gay, JM., Cantor, GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11:727-33, 2001. Pubmed reference: 11692082.