Other names: Urolithiasis
Affected gene: SLC2A9
Inheritance: Autosomal Recessive
Mutation: CanFam3.1 (chr3) g.69456869G>T, c.563G>T, p.(C188F)
OMIA link: 001033-9615

Appropriate breeds for testing: American Bulldog, American Pit Bull Terrier, American Staffordshire Terrier/Amstaff, Australian Shepherd, Black Russian Terrier, Collie, Collie - Rough, Collie - Smooth, Coton de Tulear, Dalmatian, Danish Swedish Farmdog, Drentsche Patrijshond Dutch Partridge Dog, English Bulldog, English Shepherd, Finnish Lapphund, French Bulldog, German Shepherd, German Shorthaired Pointer, Jack Russell Terrier, Jagdterrier/German Hunting Terrier, Koolie, Labrador Retriever, Lagotto Romagnolo, Large Munsterlander, Mastiff (Old English), Miniature American Shepherd, Miniature Australian Shepherd, Parson Russell Terrier, Pomeranian, Russell Terrier, Schapendoes, Schnauzer - Giant, Shiloh Shepherd, South African Boerboel, Spanish Water Dog, Swedish Vallhund, Toy Australian Shepherd, Weimaraner, White Swiss Shepherd

References: 
Bannasch, D., Safra, N., Young, A., Karmi, N., Schaible, RS., Ling, GV. :    
Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PLoS Genet 4:e1000246, 2008. Pubmed reference: 18989453. DOI: 10.1371/journal.pgen.1000246.
Karmi, N., Safra, N., Young, A., Bannasch, DL. :    
Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers. Am J Vet Res 71:909-14, 2010. Pubmed reference: 20673090. DOI: 10.2460/ajvr.71.8.909.
Karmi, N., Brown, EA., Hughes, SS., Mclaughlin, B., Mellersh, CS., Biourge, V., Bannasch, DL. :    
Estimated frequency of the canine hyperuricosuria mutation in different dog breeds. J Vet Intern Med 24:1337-42, 2010. Pubmed reference: 21054540. DOI: 10.1111/j.1939-1676.2010.0631.x.