Other Names: Factor VII Deficiency
Affected Gene: F7
Transmission: Autosomal recessive
Mutation: CanFam3.1 22 g.60578895G>A c.407G>A p.(G136E)
OMIA Link: 000361-9615

Breeds Recommended for Testing: Airedale Terrier, Alaskan Klee Kai, American Foxhound, Australian Shepherd, Beagle, Deutsch Kurzhaar, Deutsch-Drahthaar, Finnish Hound, German Shorthaired Pointer, German Wirehaired Pointer, Giant Schnauzer, Irish Water Spaniel, Japanese Spitz, Miniature American Shepherd, Miniature Australian Shepherd, Miniature Schnauzer, Papillon, Phalene, Redbone Coonhound, Scottish Deerhound, Sealyham Terrier, Welsh Springer Spaniel

Symptoms:
Factor VII deficiency is a bleeding disorder caused by a lack of Factor VII, leading to mild to moderate bleeding problems. Dogs affected by this condition, such as Beagles, may experience:
  
Excessive bleeding
  
Difficulty stopping bleeding after injuries or surgeries
The severity can range from mild to moderate, with symptoms appearing more noticeable after trauma or surgery.

References:
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA.
A novel missense mutation responsible for factor VII deficiency in research Beagle colonies.
J Thromb Haemost. 2006 Dec;4(12):2616-22. PubMed: 16961583
Carlstrom LP, Jens JK, Dobyns ME, Passage M, Dickson PI, Ellinwood NM.
Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony.
Comp Med. 2009 Aug;59(4):378-82. PubMed: 19712579
Donner J, Kaukonen M, Anderson H, Moller F, Kyostila K, Sankari S, Hytonen M, Giger U, Lohi H.
Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders.
PLoS One. 2016 Aug 15;11(8):e0161005. PubMed: 27525650