Other names: Non-Type I Cystinuria, CystIII
Affected genes: SLC3A1 and SCL7A9
Transmission: Multigene associative markers
Refers to a disease or trait influenced by DNA variations found in more than one gene or genomic location. These types of DNA variants are also called "linked markers" which are associated with the disease or trait but are not considered to be the actual causative mutation(s).
Mutation: CanFam3.1 variant 1. SLC3A1 (chr10, exon 2) g.46705989 A>G, c.574 A>G, p.(I192V)
variant 2. SLC3A1 (chr10, exon 10) g.46735617 A>G, c.2092 A>G, p.(S698G)
variant 3. SLC7A9 (chr1) g.119209134 G>A, c.649 G>A, p.(A217T)
OMIA link: 001881-9615

Appropriate breeds for testing: Bulldog, French Bulldog, Mastiff